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Motoyasu Kobayashi

Motoyasu Kobayashi

Kogakuin University, Japan

Title: Interaction between polymer brushes bearing phophorylcholine and inverse: Phophorylcholine groups

Biography

Biography: Motoyasu Kobayashi

Abstract

Phosphocholine (PC) is a zwitterion group which can be found in phosphatidylcholine lipids of the cell membrane in nature. It is widely known that the polymer bearing PC group reveals excellent bio-compatibility and antifouling properties due to extremely weak interaction between PC and protein molecules. In this work, an adhesive interaction of polyzwitterion brushes containing sulfo- and phospho-betaine groups in water was estimated by force curve measurement using scanning probe microscopy. Polyzwitterion brushes with a 110 nm thick (dry state) on a silicon wafer were prepared by surface-initiated atom transfer radical polymerization of methacrylate monomers bearing sulfobetaine (SB), PC, and inverse-PC (iPC). Inverse PC is a zwitterionic group having inverted charge orientation of quaternary amine and phosphate in contrast to PC. Chemical structure of polymers with PC and were shown in Figure 1.