30^th International Conference on Materials Chemistry & Science August 27-28, 2018 Toronto, Ontario, Canada

Research Scholar at Punjabi University and research area in synthesis and characterization of transition metal doped borosilicate glasses for radiation dosimetry.

The glasses with composition xMnO-(20-x) Li2O-50B2O3-30SiO2 (where x = 4, 6, 8 and 10 mol %) were prepared via melt and quench technique. Structural and optical properties of the samples were investigated using X-ray diffraction (XRD) and UV-visible spectroscopy. Various physical parameters viz. density, molar volume, ionic concentration and inter-nuclear distance have been calculated. The density of the samples increases with increasing MnO content due to higher molar mass of MnO as compared to Liâ‚‚O whereas the molar volume decreases. The ionic concentration increases with the increasing content of MnO while the inter-nuclear distance decreases, which results in more compact boron network in borosilicate glasses. The XRD patterns confirm the amorphous nature of the glasses. The optical band gap of the glass samples decrease with increasing content of MnO whereas the Urbach energy increases. Urbach energy is highest for maximum concentration of MnO, which indicates the maximum disorder in that glass.

Reena Tondwal has completed her MSc from Banasthali University and MPhil from Central University of Gujarat. Now she is a\r\nresearch scholar and pursuing her PhD from Central University of Gujarat, India. She has published 2 papers and 3rd paper\r\ncommunicated in reputed journals. She has her expertise in Polymer and Dendrimer Chemistry and Drug Delivery

A study of 1st tier Dendrimer series (Trimesoyl 1,3,5-tridialkyl malonate\r\nester: TTDAM) as drug delivery vehicle encapsulated with the model\r\ndrug ( Methotrexate: MTX) individually, for breast cancer drug delivery\r\nand in vitro evaluation of toxicity of serial dendrimers with their\r\ncomplexes on the breast cancer cell line suggesting new awareness for\r\ndeveloping safe breast cancer drug delivery system. MTX-TTDAMs\r\nwere prepared using a 1 : 1 ratio of MTX and TTDAM, in acetone\r\nmedium at RT followed by 24 h. MTX-TTDAMs formed by hydrogen\r\nbonding confirmed through FTIR and further characterized by SEM and\r\nDLS for their morphological and narrow particle size distribution (on nm\r\nscale) respectively. The –OH stretching frequency at 3356.2, 3352.5,\r\n3420 and 3416.3 cm-1\r\nfor MTX, MTX-TTDMM, MTX-TTDEM and\r\nMTX-TTDPM, respectively absent in dendrimer series elucidating weak\r\nhydrogen bonding between –OH and ester group. A strong stretching of\r\namide at 1648.2 cm-1\r\nin MTX, remains at same position in MTXTTDMM\r\nand MTX-TTDEM aspect MTX-TTDPM shows amide\r\nstretching at 1640.7 cm-1\r\n, confirms impact of amide group in binding.\r\nMTX-TTDPM illustrated less number of aggregates due to more binding\r\nof MTX with TTDPM and rest self-aggregate such as molecular selfassembly.\r\nTrimesoyl 1, 3, 5-tridimethyl malonate ester (TTDMM),\r\ntrimesoyl 1, 3, 5-tridiethyl malonate ester (TTDEM) and trimesoyl 1, 3,\r\n5-tridipropyl malonate ester (TTDPM) has void spaces and functionality\r\nwhich assistances to bind MTX anticancer drugs for their impending use\r\nin breast cancer drug delivery system. The higher hydrophobicity of\r\nTTDPM errands more methotrexate binding and controlled release\r\nprofiles compared to TTDMM and TTDEM. Effects of dendrimers and\r\ntheir complexes were tested on cell viability by SRB assay using a human\r\nbreast cancer cell line (MCF-7), remarkably inhibits the growth of MCF7\r\nbreast cancer cells.\r\n